well now, what an interesting debate, I'll throw these two nuggets into the mix:
first off, I used to own a bandit 600 which I actually quite enjoyed (wide MX renthals, single cable QA throttle, ignition advancer, K&N etc). however one day I was riding back from bristol on it (actually in quite similarly cold and icy weather as we have at the moment, just with a bit less snow) and you'll never guess what happened as I went to overtake a car, yes thats right the return spring snapped and I was left going down the road in about 4th gear with the throttle pinned open. I actually ended up panicing and hit the brakes which was a big no no, and ended up taking the top of my knee caps off on the supergrip that was covering the middle of the road (you know the nice red sandpaper style stuff) as I was only wearing jeans with my kit. On the flip side as has already been mentioned, if I'd hit the kill switch and pulled the clutch in I'd have been fine but it was so cold I had lost my concentration and reaction times etc.
to be honest though, it wasn't the best maintained bike before I got it, and I wasn't much better when I had it either, so as long as you keep your bike uptogether I can't see any reason why you wouldn't use one for safety reasons. I also think that the extreme cold had something to do with it as well (it was about 0 degrees C or so that day and was getting a lot colder in the evening before I left so could have been -1 or -2), as metal is more brittle when it's cold and I had ripped the throttle open as I just wanted to get home.
secondly, on the subject of road riding with a quick throttle, I actually made one for my GSXR last year as I was fed up of having to reach around the throttle to get on the gas properly and now have only 1/7 maybe 1/8 of a turn to full throttle (the bandit one was only about 1/5). When I first made it I did worry slightly about riding in town and threw traffic etc. even though I was already very smooth with the throttle, but I've actually found it's made me a lot smoother since fitting it, and I actually find it easier to sit at a constant speed (for when I have to sit at the speed limit behind a copper while I work out how to pass him legally).
So there you go, single cable can be bad if you don't keep your bike up to scratch and your really really unlucky and there's a blue moon out, but even through all of that they still get a thumbs up from me.